Applied Sciences > Medicine > N-001

Research Title Genomic Surveillance and Intervention on Dengue Virus
Research Personnel Leader:
Dr. Francisco M. Heralde

Research Duration Start:
16 April 2012
15 April 2015
Research Location Quezon City, Manila
Research Description Dengue fever, a mosquito-borne infectious disease has recently shown a widespread occurrence nationwide. In the National Capital Region, the dengue cases rose by 18.2 percent from January to October 15 compared to the same period last year based on the Department of Health’s regional epidemiology surveillance which showed 21,695 dengue cases with 123 deaths compared to 18,349 cases with 117 deaths in 2010 (Dr. Eduardo Janairo, CHD-MM regional director). Majority of the cases were males aged 15 years old and below with 13,353 cases and 109 deaths. The 10 cities with the highest number of cases were Quezon City (7,320); Manila (2,984); Caloocan City (2,368); Valenzuela City (1,321); Pasig City (1,098); Malabon City (937); Parañaque City (899); Taguig City (669); Muntinlupa City (622) and Pasay City (585). What the local communities have been doing through the years to combat dengue and why the continued rise in dengue cases, raises the question of the relevance of existing dengue control programs. Apparently, a prevalent lack of active, research-based and sustainable preventive programs are common in the different communities. It has always been a practice of various stakeholders to be “reactive” and do conventional mosquito control programs like fumigation and basic clean-up drive of stagnant waters as means to control dengue. Thus, monitoring and biosurveillance of dengue mosquito has not been built as an early warning system and neither are biotech methods installed to specifically target and control the Aedes mosquito population. In this proposal, the plan is to supplement the OL Trap program of DOST by providing avenue for submission of mosquito samples for dengue virus analysis and thus provide lead for areas vulnerable to pathogenic dengue viral strain infection. With the School-based Roll-out of the OL trap Program where DOST has already distributed a total of 34, 910 OL traps in the National Capital Region (NCR), 41,286 in Region I and 5,190 in the Cordillera Administrative Region (CAR) (Agron, 2011), this proposal becomes timely and relevant as an add-on to promote active biosurveillance of dengue virus. Secondly, it will also provide an avenue for introducing biotech-based interventions to control/vaccinate mosquito and thus control the latter's ability to infect humans.
Research Objectives To establish a viral genome surveillance of mosquito samples from mosquito-trap systems for early advisory and develop orally-deliverable anti-dengue vaccine to mosquitoes.
Research Beneficiary(ies) General public (Filipino people)
Research Accoplishments Website on Genomic Surveillance of Dengue Virus, developed and accessible online; Involvement in the pilot-testing of dengue teaching materials; Assistance to student researchers. Protocol optimization: analyzed 100 mosquito DNA samples, at least one feeding device prototype developed.
Total Research Cost
Research Agencies Funding:
UP Manila

Research Budget Breakdown Year:
Year Funded:
Total Cost
Date Released
Amount Released

Code N-001
KRA Code Poverty Reduction and Empowerment of the Poor
Priority Thrust DOST
Pressing national problems

Sector Applied Sciences
Actual Sector Anti-dengue
Related sectors Healthcare, Virology
Entry revision: January 2021