Applied Sciences > Medicine > DG CY2020 7991

Research Title Proteomic Analysis of Aberrant Protein Expression in Non-Small Cell Lung Cancer (NSCLC) (Year 2 of 3)
Research Personnel Leader:
Staff:


Research Duration Start:
End:
7 January 2019
31 October 2019
Research Location UPD-IC
Research Description This study aims to identify aberrant expression of proteins in Filipino NSCLC patients, and to discover a panel of candidate biomarkers for detection and TKI resistance monitoring, and possible drug targets. This study will also provide proteome profiles of Filipino NSCLC patients. In addition, the study can reveal potential mechanism and better understanding of NSCLC and TKI resistance. This work will also provide a great opportunity to establish a proteomics facility in the Philippines that can provide service for personnel training, and proteomics application in various other fields such in agriculture, environmental studies, or food industry.
Research Objectives This project aims to: a) establish a proteomics-based biomarker and drug target discovery protocol from clinical samples; b) train researchers and scientists in proteomic analysis; c) profile the proteome of Filipino patients suffering from NSCLC ; d) correlate the proteomic profile with TKI drug resistance in Filipino NSCLC; e) identify potential protein biomarkers and drug targets in Filipino NSCLC; and f) identify putative pathways involved in NSCLC tumorigenesis.
Research Beneficiary(ies) The main beneficiaries of this program in the health sector are healthcare providers and NSCLC patients in the Philippines. This project will also equip researchers and scientists with the knowledge and skills needed to perform the steps in proteomics-based biomarker discovery.
Research Accoplishments [CY 2018] 1) Working pipeline for proteomic analysis of clinical samples that can be applied for biomarker discovery and drug target determination; 2) Opportunities for proteomics-based researches in the Philippines; 3) Highlytrained researchers and scientists in proteomics; 4) Substantial information on the proteome profile of NSCLC Filipino patients; 5) List of candidate protein biomarkers and dug targets for Filipino NSCLC; 6) List of pathways possibly involved in NSCLC progression; 7) Insights on targeted treatment of NSCLC for personalized medicine; 8) Contribute in the understanding of the mechanism of NSCLC progression and TKI resistance
Total Research Cost ₱9,604,325.52
Research Agencies Funding:
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Monitoring:

UPD-IC


Research Budget Breakdown Year:
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Code DG CY2020 7991
KRA Code
Priority Thrust DOST
R&D


Sector Applied Sciences
Actual Sector Medical Science
Related sectors Chemistry
Entry revision: February 2021