Applied Sciences > Medicine > DG CY2020 8035

Research Title Long-Term Outcomes of Diagnosed Tuberculosis Cases in the Philippines (Year 2 of 3)
Research Personnel Leader:
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Research Duration Start:
End:
1 December 2017
30 November 2021
Research Location UPD
Research Description The Philippines still has one of the highest tuberculosis (TB) burden worldwide, despite achieving all 2015 millennium development goals in reducing TB cases and death. It was estimated that there are 324,000 new cases and 14,000 TB-related TB deaths in the Philippines.Also, despite the advances of the national tuberculosis control programme (NTP) in improving adult TB case detection and treatment, it is still unclear how effective the NTP guidelines are on TB treatment and prevention against disease-free survival, and even death. This study therefore, aims to evaluate the performance of the current NTP treatment guidelines vis-a-vis the pragmatic outcomes, namely death or recurrence-free survival. These outcomes were chosen as they reflect completion of treatment as well as the level of quality of care. In addition, the project will also assess the outcomes in children who were previously diagnosed to have TB disease, latent TB infection (LTB) or were exposed. This study will address this death of information on long term outcomes of TB treatment in the Philippines. Results from the study will be useful as it will guide future programmatic implementation of the NTP. This study also incorporates the objectives and methodologies of the Regional prospective observational research for tuberculosis (RePORT), in collaboration with the USNIH, so that TB cases from the Philippines are represented in the global effort. As of September 30, 2018, 363 of 371 possible participants in Cohort C (97%), 82 participants in cohort A, and 6 participants in Cohort B. Year 2 of the Project's implementation will see the continuation of the enrollment and followup treatment process as well as the collection of specimen.
Research Objectives To determine long-term (at least two year) outcomes of tuberculosis (TB) cases. The specific goals of this study are the following: 1. to determine rates of recurrence of TB, at least two years after end of treatment (microbiologicallyconfirmed and clinically diagnosed cases) (Cohort C); 2. to determine the outcomes of children with LTBI and those with TB expose, at least two years after the diagnosis (Cohort C); 3. to determine the rates of recurrence of TB, 3 months after the end of treatment (microbiologicallyconfirmed and clinically diagnosed cases) up to the end of the study period (Cohort A); 4. to determine the outcomes of exposed individuals to diagnosed TB cases within two years of the diagnosis of the index case (Cohort B); 5. to provide specimens to RePORT consortia biomarker researchers and their collaborators to achieve a better understanding of the prognosis of TB disease and the pathogenesis of progression from TB exposure to disease. (Cohorts A and B); 6. to identify possible factors and biomarkers that may be associated with various tuberculosis states (LTBI), recurrent TB, active disease and disease progression) (Cohorts A, B and C); and 7. to determine the strains of M. tuberculosis in Filipino patients and household contacts who eventually develop tuberculosis using molecular epidemiologic techniques and if possible, compare with previous isolates (Cohorts A, B, and C)
Research Beneficiary(ies) 1). Patients of the National TB Control Program (NTP) study sites are Los Banos and San Juan Rural Health Units and Satellite Treatment Centers; and 2). NTP Program Managers and Policymakers.
Research Accoplishments [CY 2019] 1) Results from the study will have an impact of the following policy recommendations: a. Evaluating effective of current treatment regimens on long-term outcomes of TB; b. Identifying populations at risk to develop TB relapse, re-infection or progression of TB infection to disease; c. Identifying populations who may benefit from preventive therapy; d. Use of new biomarkers to improve identification of TB infection and TB disease; 2) Results will affect TB identification, preventive and treatment practice guidelines with identification of factors (epidemiologic and clinical factors) and biomarkers that will help identify TB infection, TB disease and predict progression; 3) Results will provide genetic analysis of M. Tuberculosis strains that may be the bases or support for future molecular studies and applications; 4) Results of standardized data and specimen collection in the study will be part of RePORT Consortia where members can share and compare data for analysis for future studies.
Total Research Cost ₱23,134,776.23
Research Agencies Funding:
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UPD


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Code DG CY2020 8035
KRA Code
Priority Thrust DOST
R&D


Sector Applied Sciences
Actual Sector Medical Science
Related sectors Health care
Entry revision: February 2021